Complete the sentences with although or in spite of

............ it rained a lot, we enjoyed our holiday.
........... all my careful plans, a lot of things went wrong.
............I had planned everything carefully, a lot of things went wrong.
I love music ............ I can’t play a musical instrument.
............ being very tired, we carried on walking.
The heating was full on, but ............ this house was still cold.
Keith decided to give up his job ......... I advised him not to.
.......... she smokes 40 cigarettes a day, she is quite fit.

We can say in spite of but despite without of.
In spite of poor health, my father was always cheerful.Despite my qualifications, I didn’t get the job.We can also use despite the fact thator in spite of the fact that. He insisted on playing,despite the fact that hehad a bad cold.They ignored, this order,in spite of the fact thatthey would probably get into trouble.