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The climate has the direct and indirect effect on the person and his biorhythms

General. Does the climate have the direct and indirect effect on the person and his biorhythms?
Has the climate the direct and indirect effect on the person and his biorhythms?
Special. What effect does the climate have on the person and his biorhythms?
Whom does the climate have the direct and indirect effect?
Tag q. The climate has the direct and indirect effect on the person and his biorhythms, doesn't it?
The climate doesn't have the direct and indirect effect on the person and his biorhythms, does it?
Alternative. Does the climate have the direct or indirect effect on the person and his biorhythms?
Q to Subject. What does have the direct and indirect effect on the person and his biorhythms?